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However, finished products or mixture products to which chemically defined active substances have been added, Including synthetic compounds and/or Isolated constituents from herbal materials, are not considered to be herbal. suggested that monitoring beyond the treatment period might be unnecessary as calcifi- cations and hyperostosis in patients who had received isotretinoin for 3 years had neither progressed nor improved 10 to 24 months after the end of treatment; additionally no new hyperostoses had developed during that period. Traditional use of herbal medicines Traditional use of herbal medicines refers to the long historical use of these medicines. '° Of 25 patients treated with aciu^tin for a mean of 5 years one had abnormal calcification thought to be caused by the drug;" therapy with acitrctin was continued with no further side-ef- fects. Hypercalcemia a.ssociated with ora Ul isotretinoin in the treatment of severe acne. If more than one herb is used, the term mixture herbal product can also be used. Others have found evidence of changes after 4 months in pa- tients who had taken isotretinoin 1 mg per kg body-weight daily and recommended that radiological examinations should be made every 6 months in patients receiving isotretin- oin for more than a year.^ However, another study found that although 12% of patients receiving isotretinoin 0. Finished herbal products and mixture herbal products may contain excipients In addition to the active ingredients. S mg per kg had evidence of hmrostoses this was not clinically signifi- cant in any patient.' Tangrea et al. Impaired renal function and hypercalcaemia ^ associated with etretinate.

They refer to a broad set of health care practices that are not part of that country's own tradition and are not integrated Into the dominant health care system. The USA manufacturers have records of adverse ef- ^ fects on the lung including worsening asthma, recurrent pneu^ mothorax, interstitial fibrosis, and pulmonary granuloma.^ A study of healthy subjects confirmed that lung function tests could deteriorate after treatment with isotretinoin.^ 1 . Exercise-induced bronchoconstriction related to isotretinoin therapy.

Their use is well established and widely acknowledged to be safe and effective, and may be accepted by national authorities. The authors recommended radiological examinations after twelve months of treatment and then every second year.

Therapeutic activity ittp://int/medicines/areas/traditional/defmitions/er^^ 08/01/2006 0 I Traditional Medicine: Defmitij^ Page 2 of 2 Active Ingredients refer to Ingredients of herbal medicines with therapeutic activity. A study in 135 patients'^ who had received oral retinoids for a mean of 30 months could establish no relationship between spinal abnormalities and prolonged oral retinoid treatment and the authors suggested that spinal abnormalities only oc- cur sporadically in predisposed patients. Premature epiphyseal closure in a childs' ' giving oral 13-cis-retinoic acid.

Traditional health systems have organized frameworks for classifying plants, animals, landscapes and climatic conditions in relation to their effects on health and disease. Hepatotoxic reactions in a patient treated with etretinate.

These taxonomies have much in common with one another and represent a culturally- relevant empirical framework for assessing medicinal plant biodiversity.

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